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April 1, 1993Proceedings of the National Academy of SciencesOpen Access

Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter.

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Population

Winter flounder urinary bladder (model for cloning the cotransporter)

Design

Preclinical

Authors

GGGerardo GambaSSSamuel SaltzbergMLMaria Stella Lombardi

Discussion

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Overview

May guide future diuretic development; leaves open clinical translation pending human validation.

Structured PICO

P
Population
Winter flounder urinary bladder (model for cloning the cotransporter)
I
Intervention
Expression cloning strategy
O
Outcome
Isolation and characterization of the cDNA encoding the thiazide-sensitive sodium-chloride cotransporter

First isolation and characterization of a cDNA encoding a thiazide-sensitive sodium-chloride cotransporter, providing molecular insight into the target of thiazide diuretics.

Cite This Study

Gamba et al. (1993) studied this question.

synapsesocial.com/papers/6a815b8526f0d7dff79cd5c0https://doi.org/10.1073/pnas.90.7.2749
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