Why the study?
Does major lower extremity surgery cause changes in inflammatory, fibrinolytic, and coagulatory cascades in trauma patients?
Population
105 patients, including 83 blunt trauma patients in stable condition and 22 patients eligible for elective…
Comparison
Primary unreamed intramedullary nailing for… vs Isolated ankle fracture acutely stabilized.
Design
Cohort
Follow-up
perioperative
Authors
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May compound systemic inflammation in trauma patients; leaves open whether IL-6 monitoring or modulation alters outcomes.
Does major lower extremity surgery cause changes in inflammatory, fibrinolytic, and coagulatory cascades in trauma patients?
Major surgery of the lower extremity, such as femoral nailing, induces significant inflammatory and coagulatory responses comparable to elective total hip arthroplasty, imposing an additional burden on trauma patients.
Pape et al. (2000) studied this question.
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