What question did this study set out to answer?

To evaluate the regulation of vitamin D metabolism and calcium homeostasis in patients with hypoparathyroidism during therapy adjustments.

September 1, 1980The Journal of Clinical Endocrinology & Metabolism

Vitamin D Metabolism in Hypoparathyroidism

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Authors

BLBi. LundUniversity of California, Riverside OSO. H. SørensenUniversity of Oslo BLBi. LundUniversity of California, Riverside

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Implication

Clinical study demonstrates substrate-dependent vitamin D synthesis in hypoparathyroidism, suggesting parathyroid hormone is dispensable for basal production.

Key Points

To evaluate the regulation of vitamin D metabolism and calcium homeostasis in patients with hypoparathyroidism during therapy adjustments.
Assessed serum 25-hydroxyvitamin D [25OHD] and 1,25-dihydroxyvitamin D [1,25(OH)2D] in 13 patients with hypoparathyroidism and 1 patient with pseudohypoparathyroidism (N=14).
Monitored circulating metabolite concentrations, calcium levels, and 25OHD half-life during transition from ergocalciferol to 1 alpha-hydroxycholecalciferol (1 alpha-OHD3).
Circulating 1,25(OH)2D was only moderately reduced and correlated significantly with 25OHD levels, demonstrating substrate-driven renal production without parathyroid hormone.
Plasma 25OHD exhibited an estimated biological half-life of 3 weeks, and 1,25(OH)2D elevations correlated directly with the administered 1 alpha-OHD3 dose.
Serum calcium showed no correlation with 1,25(OH)2D concentrations, displaying unpredictable fluctuations despite stable dosing and physiological hormone levels.

Cite This Study

Lund et al. (1980) studied this question.

synapsesocial.com/papers/6a81607a267334e2baf09688 https://doi.org/10.1210/jcem-51-3-606

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Implication

Clinical study demonstrates substrate-dependent vitamin D synthesis in hypoparathyroidism, suggesting parathyroid hormone is dispensable for basal production.

Vitamin D Metabolism in Hypoparathyroidism

Discussion

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Implication

Key Points

Cite This Study

Vitamin D Metabolism in Hypoparathyroidism

Discussion

Member takes

Implication

Key Points

Cite This Study

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