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In 87 epileptics on diphenylhydantoin, the occurrence of non-seizure-related fractures, over a period of 7 years, was six times greater than that found in the normal population. The significant increase in fracture incidence was found to lie within the 45-64 age group indicating that eipleptics are not only more prone to fractures but also have an earlier fracture début.
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Lidgren et al. (1977) studied this question.
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