Why the study?
Does altering the silicon concentration in pyrolytic carbon valve leaflets affect human platelet responses in vitro?
Population
Human platelets (in vitro model)
Comparison
Pyrolytic carbon valve leaflets with varying… vs Different concentrations of silicon
Design
Preclinical
Authors
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Silicon concentration in pyrolytic carbon may not affect platelet adhesion; leaves open in vivo effects on mechanical valve thrombogenicity.
Does altering the silicon concentration in pyrolytic carbon valve leaflets affect human platelet responses in vitro?
Altering the silicon alloy concentration in pyrolytic carbon mechanical heart valves over a range of 0.54-13.5 wt % is unlikely to alter in vivo blood compatibility.
Goodman et al. (2007) studied this question.
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