reaction, both with and without a Lewis acid catalyst.If all isomers are formed from a common transition state, the re- action should yield the same product distribution at all pres- sures, whereas if two or more transition states are involved, the distribution would be pressure dependent.For example, if the system studied by Thompson and Melillo (1970) pro- ceeds through multiple transition states, the product distribu- tion should vary with pressure, as it does for chloroprene (Stewart, 1971(Stewart, , 1972)).Moreover, if any two or more of the products appear in the same ratio, regardless of variations in pressure or solvent, they probably proceed through the same transition state.Finally, and perhaps most important, the application of high-pressure kinetics has been demonstrated as an experi- mental tool to study the detailed role of the catalyst in a homogeneously catalyzed liquid-phase reaction.Used in conjunction with other types of data, a high-pressure kinetics experiment is clearly capable in many cases of yielding new and valuable information about mechanisms of catalysis.
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Fernbacher et al. (1972) studied this question.