April 29, 2006AJP Heart and Circulatory Physiology

Preconditioning by 17β-estradiol in isolated rat heart depends on PI3-K/PKB pathway, PKC, and ROS

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Why the study?

Does 17beta-estradiol preconditioning reduce infarct size in isolated rat hearts subjected to ischemia-reperfusion?

Population

Isolated rat hearts (male and female)

Comparison

17beta-estradiol preconditioning before 30 min… vs Control

Design

Preclinical

Follow-up

2 hours of reperfusion

Authors

MSMikhail A. Sovershaev181st Hospital of Chinese People's Liberation Army EEElena M. EgorinaUniversity Hospital of North Norway TAThomas V. Andreasen

Discussion

Member takes

Implication

Does not support clinical adoption of E2 preconditioning; leaves open translational studies to confirm cardioprotection in humans.

Structured PICO

Does 17beta-estradiol preconditioning reduce infarct size in isolated rat hearts subjected to ischemia-reperfusion?

Population

Isolated rat hearts (male and female)

Intervention

17beta-estradiol (E2) preconditioning (three 5-min cycles of 10 microM E2) before 30 min of regional ischemia, followed by 2 h of reperfusion, with or without inhibitors (wortmannin, chelerythrine, 2-mercaptopropionylglycine)

Comparator

Control (hearts without E2 preconditioning or E2 combined with inhibitors)

Outcome

Infarct size in percentage of risk zone volumesurrogate

17beta-estradiol induces preconditioning-like cardioprotection against ischemia-reperfusion injury in isolated rat hearts via PI3-K/PKB, PKC, and ROS signaling pathways.

Cite This Study

Sovershaev et al. (2006) studied this question.

synapsesocial.com/papers/6a81631d71edfdad573c7be0 https://doi.org/10.1152/ajpheart.01171.2005

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Preconditioning by 17β-estradiol in isolated rat heart depends on PI3-K/PKB pathway, PKC, and ROS

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Preconditioning by 17β-estradiol in isolated rat heart depends on PI3-K/PKB pathway, PKC, and ROS

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider