Why the study?
Hand, foot and mouth disease is a public health threat, with enterovirus A71, coxsackievirus A16, and CVA6 as major outbreak pathogens in countries such as Thailand.
Population
385 VP1 nucleotide sequences (228 EV-A71, 33 CVA16, and 124 CVA6) deposited between 2000 and 2022
Design
Molecular evolutionary characterization study using Bayesian phylogeny
Authors
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Supports expanded enteroviral surveillance to anticipate HFMD emergence; leaves open vaccine strain selection based on cryptic lineages.
The study demonstrates the fluctuation and cyclical pattern of HFMD-causing viruses in Thailand over two decades, providing insights for genotype-matched vaccine selection and development.
Noisumdaeng et al. (2023) studied this question.
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