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May 20, 2014Hypertension78 citationsOpen Access

Elevated Testosterone Levels During Rat Pregnancy Cause Hypersensitivity to Angiotensin II and Attenuation of Endothelium-Dependent Vasodilation in Uterine Arteries

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Why the study?

Does elevated testosterone impair uterine vascular function in pregnant rats?

Population

Pregnant Sprague-Dawley rats (n=40)

Comparison

Testosterone propionate vs Vehicle injection

Design

Preclinical

Follow-up

Gestation day 15 to 19

Authors

VCVijayakumar ChinnathambiCBChellakkan S. BlessonKVKathleen L. Vincent

Discussion

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Overview

May implicate maternal hyperandrogenism in impaired uterine perfusion; hypothesis-generating and requires human validation.

Structured PICO

Does elevated testosterone impair uterine vascular function in pregnant rats?

P
Population
Pregnant Sprague-Dawley rats (n=40)
I
Intervention
Testosterone propionate (0.5 mg/kg per day from gestation day 15 to 19)
C
Comparator
Vehicle injection
O
Outcome
Uterine artery contractile and relaxation responsessurrogate

Elevated maternal testosterone impairs uterine vascular function in pregnant rats, potentially increasing vascular resistance and decreasing uterine blood flow.

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Cite This Study

Chinnathambi et al. (2014) studied this question.

synapsesocial.com/papers/6a81662e7766956b633ca27bhttps://doi.org/10.1161/hypertensionaha.114.03283
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