November 1, 2003AJP Heart and Circulatory Physiology

Responsiveness vs. basal activity of plasma ANG II as a determinant of arterial pressure salt sensitivity

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Population

Sprague-Dawley rats instrumented with arterial and venous catheters (n=42)

Comparison

Administration of enalapril, enalapril + 5… vs Saline control

Design

Preclinical

Follow-up

14 days

Authors

JOJohn W. OsbornUniversity of Minnesota Medical Center PAPilar Ariza-NietoUniversity of Minnesota JCJohn P. CollisterUniversity of Minnesota

Discussion

Member takes

Implication

Basal ANG II may determine salt sensitivity in rats; leaves open translation to human hypertension.

Structured PICO

Population

Sprague-Dawley rats instrumented with arterial and venous catheters (n=42)

Intervention

Administration of enalapril (ANG-Lo), enalapril + 5 ng.kg(-1).min(-1) ANG II (ANG-Norm), or enalapril + 20 ng.kg(-1).min(-1) ANG II (ANG-Hi)

Comparator

Saline control

Outcome

Salt sensitivity (change in arterial pressure divided by the change in sodium intake on the last day of the 4.0% NaCl diet)surrogate

The basal level of plasma ANG II, rather than the responsiveness of the renin-angiotensin system, is the major determinant of salt sensitivity of arterial pressure in rats.

Cite This Study

Osborn et al. (2003) studied this question.

synapsesocial.com/papers/6a81683cfd865eccc6660923 https://doi.org/10.1152/ajpheart.00200.2003

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Responsiveness vs. basal activity of plasma ANG II as a determinant of arterial pressure salt sensitivity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Responsiveness vs. basal activity of plasma ANG II as a determinant of arterial pressure salt sensitivity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider