Why the study?
Are high normal cholesterol levels associated with impaired endothelium-dependent vasodilation in normal volunteers?
Population
Normal volunteers with total cholesterol levels within the normal range (<75th percentile), n=33
Comparison
High normal cholesterol levels vs Low normal cholesterol levels (mean 146+/-5 mg/dL)
Design
Cross-sectional
Authors
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High-normal cholesterol was associated with endothelial dysfunction; hypothesis-generating for early vascular risk before overt hypercholesterolemia.
Are high normal cholesterol levels associated with impaired endothelium-dependent vasodilation in normal volunteers?
Cholesterol levels in the high normal range are associated with impaired endothelium-dependent vasodilation, suggesting early endothelial dysfunction even before clinical hypercholesterolemia.
Steinberg et al. (1997) studied this question.
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