What question did this study set out to answer?

To evaluate the clinical application and feasibility of combined intravenous insulin and subcutaneous heparin in lowering serum triglycerides in patients with hypertriglyceridemia-induced acute pancreatitis.

January 1, 2007World Journal of Gastroenterology

Insulin and heparin in treatment of hypertriglyceridemia-induced pancreatitis

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Population

2 patients with hypertriglyceridemia-induced pancreatitis.

Design

Case_series

Authors

PJPankaj JainThe University of Sydney

Discussion

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Implication

May support insulin-heparin in hypertriglyceridemia pancreatitis cases; leaves open confirmation via randomized trials before practice change.

Key Points

To evaluate the clinical application and feasibility of combined intravenous insulin and subcutaneous heparin in lowering serum triglycerides in patients with hypertriglyceridemia-induced acute pancreatitis.
Treated two patients presenting with recurrent acute pancreatitis and severe hypertriglyceridemia (N=2) after ruling out other etiologies.
Administered continuous regular insulin in 5% dextrose infusion to maintain blood glucose between 150–200 mg/dL alongside subcutaneous heparin (5000 U twice daily) plus conservative management.
Both patients presented with lipemic serum and admission serum triglyceride concentrations exceeding 1000 mg/dL.
Therapy targeting lipoprotein lipase activation via insulin and heparin facilitated triglyceride reduction and successful clinical management of acute pancreatitis without requiring plasmapheresis.

Structured PICO

Population

2 patients with hypertriglyceridemia-induced pancreatitis (recurrent acute pancreatitis, serum triglycerides > 1000 mg/dL at admission, normal liver function tests and calcium).

Intervention

Regular insulin in 5% dextrose infusion (to maintain blood sugar 150-200 mg/dL) and heparin 5000 U subcutaneously twice a day, in addition to conservative treatment.

Insulin and heparin may be used as an alternative treatment for hypertriglyceridemia-induced pancreatitis to enhance lipoprotein lipase activity.

Cite This Study

Pankaj Jain (2007) studied this question.

synapsesocial.com/papers/6a816ae0da9cafc35e33a8ed https://doi.org/10.3748/wjg.v13.i18.2642

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Implication

May support insulin-heparin in hypertriglyceridemia pancreatitis cases; leaves open confirmation via randomized trials before practice change.

Insulin and heparin in treatment of hypertriglyceridemia-induced pancreatitis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Insulin and heparin in treatment of hypertriglyceridemia-induced pancreatitis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider