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May 16, 2011Developmental Medicine & Child NeurologyOpen Access

No change in calf muscle passive stiffness after botulinum toxin injection in children with cerebral palsy

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Authors

AAAdel A. AlhusainiJCJack CrosbieRSRoberta B. Shepherd

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Overview

Interventional study demonstrates unchanged passive muscle stiffness after botulinum toxin in children with cerebral palsy, suggesting additional therapies are necessary.

Key Points

  • To investigate whether botulinum toxin type A injections alter non-neurally mediated calf muscle tightness and passive stiffness in children with cerebral palsy.
  • Evaluated 16 children with spastic cerebral palsy (7 females, 9 males; age range 4–10 y; Gross Motor Function Classification System levels I–II) before and during the active phase of botulinum toxin type A (BoNT-A) injection.
  • Measured passive muscle compliance, viscoelastic responses, hysteresis, and the gradient of the torque-angle curve during passive ankle movement.
  • BoNT-A injection produced a slight, significant increase in ankle range of motion and a small, significant decrease in the torque required to reach plantigrade and 5° dorsiflexion.
  • No statistically significant difference in myotendinous stiffness or hysteresis was detected following BoNT-A injection, indicating unchanged mechanical muscle compliance.

Cite This Study

Alhusaini et al. (2011) studied this question.

synapsesocial.com/papers/6a816ddcb3060df1303bf5c2https://doi.org/10.1111/j.1469-8749.2011.03930.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Longer‐term imaging of muscle quality after routine <scp>BoNT</scp> ‐A care in cerebral palsy: Beyond muscle volume2026
  2. 2Effect of Botulinum Toxin Type-A on Improvement of Muscle Function of Lower Limb in Children with Spastic Cerebral Palsy2024
  3. 3Proteomic changes of botulinum neurotoxin injection on muscle growth in children with spastic cerebral palsy2024 · 2 citations
  4. 4Does botulinum neurotoxin A make walking easier in children with cerebral palsy? A randomized clinical trial2024 · 3 citations
  5. 5Botulinum Toxin Type A: Efficacy in the management of Lower Limb Spasticity in Children with Genetic Disorders2024