Why the study?
Does once daily aspirin provide stable 24-hour antiplatelet protection in patients with stable coronary artery disease?
Population
150 consecutive patients with stable coronary artery disease (CAD)
Design
Cohort
Follow-up
24 hours
Authors
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May not sustain 24-hour antiplatelet effect with once-daily aspirin in stable CAD; hypothesis-generating, should not change practice.
Does once daily aspirin provide stable 24-hour antiplatelet protection in patients with stable coronary artery disease?
A significant proportion of stable CAD patients exhibit a progressive loss of aspirin-induced antiplatelet efficacy over a 24-hour period, challenging the assumption of stable 24-hour protection.
Vermillet et al. (2010) studied this question.
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