The Association between the Trajectory of the Life’s Essential 8 and Long-term Blood Pressure Variability: The Kailuan Study

This study aims to explore the relationship between the Trajectory of the Life’s Essential 8 and long-term blood pressure variability (BPV). A prospective cohort study was conducted using participants from Kailuan Group who participated in health examinations from 2006 to 2012, had no missing data in eight health indicators, and had complete baseline systolic and diastolic blood pressure data in 2006, as well as those with a history of myocardial infarction, cerebrovascular infarction, malignancy, or atrial fibrillation, were excluded. A total of 24 158 participants were included in the final cohort. We used four LE8 (Life’s Essential 8) scores from 2006 to 2012 to analyze their trajectories. To classify distinct trajectory groups within the study population, we employed latent class mixed models using the PROC TRAJ procedure in SAS. After comprehensive consideration, four distinct trajectories were identified. Subsequently, generalized linear regression models were applied to examine the association between LE8 score trajectories and blood pressure variability (BPV). Result:1 The overall population’s SCV was 8 .42%, with the Very low-stable,Low-stable, the Median-stable and the High-stable trajectory showing SCVs of 8.83%, 8.53%, 8.34%, and 8.16%, respectively.There were statistically significant differences between the groups (P<0.05). The overall population’s DCV was 7.93%, with the Very low-stable, Low-stable, the Median-stable and the High-stable trajectory showing SCVs of 8.16%, 8.04%, 7.87%, and 7.70%, respectively.There were statistically significant differences between the groups (P<0.05). 2. The generalized Linear Regression of trajectories of LE8 and SCV, after adjusting for other risk factors, showed that compared to the Very low-stable trajectory, the SCV in the Low-stable, the Median-stable and the High-stable trajectory decreased by 0.227% (P <0.05), 0.392% (P < 0.05) and 0.347% (P < 0.05), respectively. It was also found that after adjusting for other risk factors, showed that compared to the Very low-stable trajectory, the DCV in the Low-stable, the Median-stable and the High-stable trajectory decreased by 0.193% (P >0.05), 0.332% (P < 0.05) and 0.431% (P < 0.05), respectively. Conclusion the trajectories of Life’s essential 8 is negatively correlated with long-term blood pressure variability.