Covering: Mid-2000 to 2002. Previous reviews: Nat. Prod. Rep., 2001, 18, 231–281; Nat. Prod. Rep., 2001, 18, 190–227.This review covers the biosynthesis of aliphatic and aromatic polyketides as well as mixed polyketide/NRPS metabolites, and discusses the molecular genetics and enzymology of the proteins responsible for their formation.
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Alison M. Hill (2005) studied this question.