Why the study?
Does cerebroventricular infusion of P-113 reduce water intake in rats deprived of water for 30 hours?
Does cerebroventricular infusion of P-113 reduce water intake in rats deprived of water for 30 hours?
Angiotensin II plays a physiological role in the drinking response of rats deprived of water.
Answers are grounded in this paper and cite their sources.
Supports angiotensin II's role in rat thirst; leaves open translation to human cardiovascular fluid balance.
Cerebroventricular infusion of P-113, the blocking agent of angiotensin II, into rats for 75 minutes prior to their being allowed to drink, significantly attenuated their water intake when they had been deprived of water for 30 hours. However, a similar infusion had no effect on the food intake in rats fasted for 30 hours. The results indicate a physiological role for angiotensin II in the drinking response of rats deprived of water.
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Malvin et al. (1977) studied this question.
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