Why the study?
Endothelial dysfunction contributes to the pathogenesis and progression of T2DM and cardiovascular disease, and freshly isolated human endothelial cells offer new translational opportunities to uncover mechanisms and assess therapies.
This review highlights the utility of freshly isolated human endothelial cells (FIHECs) in translational research to understand and target endothelial dysfunction in type 2 diabetes.
Supports FIHEC use for T2DM endothelial studies; extends translational methods but leaves clinical adoption open.
Endothelial dysfunction contributes to the pathogenesis and progression of type 2 diabetes mellitus (T2DM) and cardiovascular disease. Endothelial dysfunction in T2DM has been studied extensively using experimental models and human studies using noninvasive assessment of vasomotor function. Recent work has also demonstrated the feasibility of translational research using freshly isolated human endothelial cells (FIHECs) to uncover novel mechanisms of endothelial dysfunction in T2DM. This review provides an overview of the relationship between endothelial dysfunction and cardiometabolic disease, with an emphasis on novel mechanisms of endothelial dysfunction in T2DM that have been uncovered in FIHECs. We then discuss how FIHECs could be used in the assessment of the vascular benefits of current and future therapeutic treatments for patients with T2DM.
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Okazaki et al. (2025) studied this question.
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