Key result
Pharmacological therapies including statins, fibrates, ACE inhibitors, and metformin improve endothelial function in type 2 diabetes, though clinical endpoint data for combination regimens are lacking.
Why the study?
Do various pharmacological therapies improve endothelial dysfunction in patients with type 2 diabetes mellitus?
Do various pharmacological therapies improve endothelial dysfunction in patients with type 2 diabetes mellitus?
This review highlights that while several monotherapies and combinations improve endothelial dysfunction in type 2 diabetes, further large clinical trials are needed to confirm hard clinical outcome benefits for many of these agents.
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Supports considering these monotherapies for endothelial benefits in T2DM; leaves open outcome data for combinations.
Hamilton et al. (2007) conducted a review in Type 2 diabetes mellitus. Pharmacological therapies (statins, fibrates, ACE inhibitors, metformin) was evaluated. Pharmacological therapies including statins, fibrates, ACE inhibitors, and metformin improve endothelial function in type 2 diabetes, though clinical endpoint data for combination regimens are lacking.
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