Key result
Linked insulin effects on glucose transport and NO production may explain endothelial dysfunction in insulin resistance.
Why the study?
The mechanisms underlying endothelial dysfunction in normoglycaemic first-degree relatives and insulin resistant subjects are less well understood and less explained by confounding variables.
Population
Patients with type 2 diabetes, insulin resistance, and normoglycaemic first-degree relatives
Design
Review
Authors
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No immediate practice change in diabetes care; leaves open whether this molecular link yields new CVD prevention targets.
Understanding the molecular link between insulin resistance and endothelial nitric oxide production may lead to novel cardiovascular disease prevention strategies in diabetic and non-diabetic subjects.
Storey et al. (2001) conducted a review in Type 2 diabetes and endothelial dysfunction. Insulin's effects on glucose transport and endothelial nitric oxide production may be fundamentally linked at a molecular level, explaining endothelial dysfunction in insulin-resistant states.