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January 1, 2003The British Journal of Diabetes

Review: Endothelial dysfunction and pre-symptomatic atherosclerosis in type 1 diabetes — pathogenesis and identification

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Population

Patients with type 1 diabetes

Design

Review

Authors

DBDuncan L. BrowneDMDarryl MeekingKSKenneth Shaw

Discussion

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Overview

No immediate clinical implications in type 1 diabetes; leaves open whether targeting these pathways improves outcomes.

Structured PICO

P
Population
Patients with type 1 diabetes

Improved understanding of endothelial dysfunction in type 1 diabetes may facilitate the development of novel diagnostic tools and interventions for accelerated atherosclerosis.

Cite This Study

Browne et al. (2003) studied this question.

synapsesocial.com/papers/6a891110185d41e08f75feefhttps://doi.org/10.1177/14746514030030010401
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Review: Endothelial dysfunction in type 2 diabetes2001 · 20 citations
  2. 2Review: Type 2 diabetes — implications for macrovascular mechanics and disease2002 · 8 citations
  3. 3Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.1993 · 1,133 citations
  4. 4Insulin Stimulates Both Endothelin and Nitric Oxide Activity in the Human Forearm1999 · 304 citations
  5. 5Impaired Insulin-Mediated Skeletal Muscle Blood Flow in Patients With NIDDM1992 · 458 citations