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January 1, 2000Seminars in Thrombosis and Hemostasis

Endothelial dysfunction in diabetes is multifactorial, involving increased endothelin-1, impaired NO function, and enhanced vascular permeability, suggesting no single therapeutic approach will solve vascular complications.

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Population

Patients with diabetes mellitus and impaired glucose tolerance

Design

Review

Authors

SSStephan SchiekoferSigmund Freud Privatuniversität WienBBBernd BalletshoferGTx (United States)MAMartin AndrassyVascular / Pulmonary Vascular

Discussion

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Overview

Multifactorial endothelial dysfunction cautions against single-target vascular therapies in diabetes; leaves open optimal multi-pathway combinations for trials.

Structured PICO

P
Population
Patients with diabetes mellitus and impaired glucose tolerance

The review highlights the complex, multifactorial nature of endothelial dysfunction in diabetes, emphasizing that a multi-targeted therapeutic approach is likely needed to address vascular complications.

Cite This Study

Schiekofer et al. (2000) studied this question.

synapsesocial.com/papers/6a71a8d16ceb2bbd16e0348dhttps://doi.org/10.1055/s-2000-13206
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial dysfunction in diabetes2000 · 1,168 citations
  2. 2Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endothelium2005 · 116 citations
  3. 3Review: Endothelial dysfunction in type 2 diabetes2001 · 20 citations
  4. 4Pathophysiological Association between Diabetes Mellitus and Endothelial Dysfunction2021 · 183 citations
  5. 5Novel mechanisms of endothelial dysfunction in diabetes2010 · 53 citations