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December 26, 2011Current Vascular Pharmacology

Diabetes Mellitus and Vascular Endothelial Dysfunction: Current Perspectives

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Population

Patients with diabetes mellitus (specifically type 2 DM)

Design

Review

Authors

DTDimitris TousoulisAKAnna–Maria KampoliCSChristodoulos Stefanadis

Discussion

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Overview

Offers clinicians a consolidated view of endothelial dysfunction in diabetes; leaves open which therapies merit prospective validation.

Structured PICO

P
Population
Patients with diabetes mellitus (specifically type 2 DM)
I
Intervention
Therapeutic approaches including statins, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), antioxidants, tetrahydrobiopterin (BH4), asymmetric dimethylarginine (ADMA), and homocysteine (tHcy)

This review highlights the mechanisms of endothelial dysfunction in diabetes and summarizes therapeutic approaches to ameliorate it.

Cite This Study

Tousoulis et al. (2011) studied this question.

synapsesocial.com/papers/6a7ff8972cf87dafd7c85c58https://doi.org/10.2174/157016112798829797
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diabetes and Endothelial Dysfunction: A Clinical Perspective2001 · 629 citations
  2. 2Diabetes and Endothelial Dysfunction: A Clinical Perspective2001 · 155 citations
  3. 3Endothelial Dysfunction in Diabetes Mellitus2000 · 71 citations
  4. 4Pathophysiological Association between Diabetes Mellitus and Endothelial Dysfunction2021 · 183 citations
  5. 5Diabetes-induced edothelial dysfuction: Molecular pathways and clinical implication2025 · 1 citations