Why the study?
Prehypertension and its progression to hypertension are prevalent, but the impact of treating prehypertension on cardiovascular outcomes remains unknown, and the mechanisms by which genetic factors contribute to hypertension are unclear.
Early detection of altered autonomic states and lifestyle interventions in prehypertensive individuals may reduce the prevalence of hypertension.
Supports autonomic screening in prehypertension; leaves open whether targeted interventions prevent progression to hypertension.
The prevalence of prehypertension and its progression to hypertension is high. Till date, the impact of treatment of prehypertension on CVD outcome is still unknown. Altered sympathovagal balance is the early manifestation of the cardiovascular dysregulation. This imbalance is improved with adaptation to a healthier lifestyle which prevents the occurrence of HTN and pre-HTN. This complex phenotype of human hypertension is partly genetically determined, but the mechanism by which these individual genes are responsible for HTN is not clear. This review studied the effects of PHTN on HTN, on heart structure, vascular structure and Sympathovagal imbalance. In conclusion, this review showed that autonomic functions are disturbed in PHTN with family history of hypertension and in those without it. Early detection of altered autonomic states and timely intervention like adoption of healthy lifestyle measures in people with PHTN may reduce the prevalence of HTN
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Dalia Biswas (2022) studied this question.
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