Key result
Parental history of hypertension in prehypertensive individuals was associated with a significantly elevated LF:HF ratio (p=0.023) and increased atherogenic lipid profile parameters.
Why the study?
Prehypertensives face an increased risk of hypertension and cardiovascular diseases, but the role of parental history of hypertension on sympathovagal balance and lipid profile parameters in this group requires evaluation.
Does parental history of hypertension alter sympathovagal balance and serum lipid profile parameters in prehypertensive individuals?
Cross-Sectional (n=60)
No
Does parental history of hypertension alter sympathovagal balance and serum lipid profile parameters in prehypertensive individuals?
p-value: p=0.023
Parental history of hypertension in prehypertensive individuals is associated with increased sympathetic drive and dyslipidemia, suggesting a higher cardiovascular risk profile that may warrant early lifestyle interventions.
May flag familial risk in prehypertensives; leaves open whether HRV or lipid monitoring alters outcomes.
Background: Parental history and dyslipidemia are the most important non modifiable risk factor and modifiable risk factor for developing hypertension respectively. Many research studies have documented the role of the autonomic nervous system in the control of blood pressure. And heart rate variability is a non-invasive tool to assess the sympathovagal balance. Prehypertensives are at an increased risk of developing hypertension and other cardiovascular diseases. Hence our study aims at evaluating the role of parental history of hypertension on the sympathovagal balance and serum lipid profile parameters in prehypertensive individuals. Aims & Objectives: The aim of the study was To assess the sympathovagal balance by recording the frequency domain parameters of heart rate variability in prehypertensives with and without parental history of hypertension. To estimate the serum lipid profile parameters in prehypertensives with and without parental history of hypertension. To correlate sympathovagal balance (LF:HF ratio) and serum lipid profile parameters in them. Methods: Study Area: Institute of Physiology and Experimental Medicine, Madras Medical College, Chennai, Tamilnadu, India. Study Population: Prehypertensive individuals with systolic blood pressure between 120 – 139mmHg or Diastolic blood pressure between 80 – 89mmHg. Sample size: 60 prehypertensive individuals (30 with parental history and 30 without parental history of hypertension) selected from non-communicable diseases clinic, Rajiv Gandhi Government General Hospital, Tamilnadu, Chennai. Results: There was no significant difference in age, body mass index between the prehypertensives with and without parental history. There was increased sympathetic drive in prehypertensives with parental history and the sympathovagal balance was altered and was suggestive of sympathetic overactivity in them. The serum lipid profile parameters like total cholesterol, Triglycerides, Low density lipoprotein was significantly elevated in prehypertensives with parental history. Also the increase in lipid profile parameters (total cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein) correlated with increase in the sympathovagal imbalance. A decrease in high density lipoprotein correlated with the increase in sympathovagal imbalance in prehyperetensives with parental history.
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Karunamoorthy et al. (2023) conducted a cross-sectional in Prehypertension (n=60). Parental history of hypertension vs. No parental history of hypertension was evaluated on LF:HF ratio (p=0.023). Parental history of hypertension in prehypertensive individuals was associated with a significantly elevated LF:HF ratio (p=0.023) and increased atherogenic lipid profile parameters.
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