Why the study?
Does vagal nerve activation provide cardioprotection in cardiovascular diseases?
Does vagal nerve activation provide cardioprotection in cardiovascular diseases?
Vagal nerve activation represents a promising therapeutic approach for cardiovascular diseases through multiple cardioprotective mechanisms including anti-inflammatory and mitochondrial regulation.
May support vagal activation as cardioprotective strategy; leaves open confirmation in prospective clinical trials.
The physiological activities of the mammalian heart are regulated by the autonomic nervous system. An imbalanced autonomic nervous system with increased sympathetic tone and reduced vagal tone has been implicated in cardiovascular diseases. Experimental and clinical reports have demonstrated that vagal nerve activation is able to improve outcomes for multiple cardiovascular diseases, such as ischaemic heart disease, heart failure, arrhythmia and hypertension. In this paper, we mainly focus on the potential cardioprotective mechanisms of vagal nerve activation. Based on the knowledge gained from our experiments and other published reports, vagal activation results in cardioprotection is not only associated with heart rate, anti-adrenergic effect but also related to anti-inflammatory activity, regulation of cellular redox states and regulation of mitochondrial targets. In conclusion, vagal nerve activation may be a promising new therapeutic approach for the treatment of cardiovascular diseases.
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Zhao et al. (2011) studied this question.
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