Population
Hyperlipidemic and normolipemic mice, and cultured murine valvular interstitial cells isolated from…
Comparison
TNF-α exposure and Smad6 knockdown via… vs Normolipemic mice; control cells without TNF-α…
Design
Preclinical
Authors
Loading...
Hypothesis-generating for Smad6 as a target in calcific aortic valve disease; human studies required before clinical consideration.
Smad6 plays a protective role against inflammation-induced valvular cell calcification by inhibiting BMP-2 signaling, suggesting a potential therapeutic target for calcific aortic valve disease.
Li et al. (2015) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: