Prevention of post-traumatic clinical capillary leak syndrome

Systemic capillary leak is an early feature of the inflammatory response to localized injury, and is proportional to the severity of the inflammatory insult. Loss of local control of inflammation leads to an exaggerated systemic inflammatory response known as systemic inflammatory response syndrome (SIRS). SIRS is associated with multiple organ failure and death when there is failure to maintain homeostasis. Whilst the application of molecular biology and recombinant techniques have produced major advances in our understanding of the mediation of the inflammatory response, there is no agent currently available which will prevent SIRS and reduce the incidence of post-traumatic multiple organ failure. In the meantime, a more practical approach to the avoidance of SIRS and its attendant capillary leak syndrome is to attempt to reduce the deleterious effects of interstitial oedema by tailoring treatment to the rapid changes in capillary permeability.