Why the study?
Does CaMK4 gene deletion or genetic variation induce hypertension and cardiovascular damage?
Population
CaMK4(-/-) mice and a population of hypertensive patients
Comparison
CaMK4 gene deletion and rs10491334 variant vs Wild-type littermates
Design
Preclinical
Authors
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CaMK4 deletion promotes hypertension and ischemic vulnerability in mice; leaves open whether CaMKIV modulation benefits human hypertension or post-MI outcomes.
Does CaMK4 gene deletion or genetic variation induce hypertension and cardiovascular damage?
CaMKIV plays a pivotal role in blood pressure regulation through the control of endothelial nitric oxide synthase activity, and its deletion or genetic variation is associated with hypertension.
Santulli et al. (2012) studied this question.
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