What question did this study set out to answer?

To evaluate the role of the transcription factor NF-Y in regulating myeloid cell function, survival, and inflammatory vascular disease progression.

August 16, 2026Journal of Leukocyte Biology

The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease

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Authors

CSCarlos Silvestre-Roig JGJose Maria Gonzalez-Granado COCollins Osei-Sarpong

Discussion

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Overview

Preclinical study reveals that myeloid NF-Y deficiency exacerbates atherosclerosis and vascular injury in mice, indicating NF-Y acts as a protective survival factor against vascular inflammation.

Key Points

To evaluate the role of the transcription factor NF-Y in regulating myeloid cell function, survival, and inflammatory vascular disease progression.
Analyzed NF-Y subunit expression across myeloid cell populations using integrated single-cell transcriptomics in mouse models.
Engineered myeloid-specific NF-YA knockout mice to assess immune cell adhesion, apoptosis, acute inflammation, atherosclerosis plaque stability, and injury-induced neointimal thickening.
NF-YA deficiency impaired neutrophil rolling and adhesion, promoted macrophage lipid accumulation and activation, and significantly increased apoptosis in both cell types.
Myeloid NF-YA deletion reduced circulating neutrophils, expanded atherosclerotic necrotic cores, and aggravated both atherosclerosis lesion size and injury-induced neointimal thickening in vivo.

Cite This Study

Silvestre-Roig et al. (2026) studied this question.

synapsesocial.com/papers/6a8178fcf2fb91fc834ac2f2 https://doi.org/10.1093/jleuko/qiag113

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August 16, 2026Journal of Leukocyte Biology

The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease

View Full Paper

Ask AI

Bookmark

Authors

CSCarlos Silvestre-Roig JGJose Maria Gonzalez-Granado COCollins Osei-Sarpong

Discussion

Member takes

Overview

Preclinical study reveals that myeloid NF-Y deficiency exacerbates atherosclerosis and vascular injury in mice, indicating NF-Y acts as a protective survival factor against vascular inflammation.

Key Points

To evaluate the role of the transcription factor NF-Y in regulating myeloid cell function, survival, and inflammatory vascular disease progression.
Analyzed NF-Y subunit expression across myeloid cell populations using integrated single-cell transcriptomics in mouse models.
Engineered myeloid-specific NF-YA knockout mice to assess immune cell adhesion, apoptosis, acute inflammation, atherosclerosis plaque stability, and injury-induced neointimal thickening.
NF-YA deficiency impaired neutrophil rolling and adhesion, promoted macrophage lipid accumulation and activation, and significantly increased apoptosis in both cell types.
Myeloid NF-YA deletion reduced circulating neutrophils, expanded atherosclerotic necrotic cores, and aggravated both atherosclerosis lesion size and injury-induced neointimal thickening in vivo.

Cite This Study

Silvestre-Roig et al. (2026) studied this question.

synapsesocial.com/papers/6a8178fcf2fb91fc834ac2f2 https://doi.org/10.1093/jleuko/qiag113

View Full Paper

Ask AI

Bookmark