Why the study?
Are remnant-like particles (RLP) oxidized to a greater extent than total VLDL in patients with ischemic heart disease, diabetes mellitus, and normal subjects?
Are remnant-like particles (RLP) oxidized to a greater extent than total VLDL in patients with ischemic heart disease, diabetes mellitus, and normal subjects?
Answers are grounded in this paper and cite their sources.
Remnant-like particles are more highly oxidized than total VLDL and are elevated in patients with ischemic heart disease and diabetes, suggesting a role in atherosclerosis progression.
Remnant-like particles (RLP) are reportedly involved in the pathogenesis of atherosclerosis, as are lipid peroxides. To assess the role of the oxidation of RLP in this disease, we compared the oxidation of RLP with that of total very low density lipoproteins (VLDL) obtained from the serum of 10 patients with ischemic heart disease (IHD), 10 patients with diabetes mellitus (DM) and 10 normal subjects by measuring the levels of thiobarbituric acid reactive substances (TBARS). Our results indicated that RLP were oxidized in vivo to a greater extent than total VLDL in all three groups of subjects. The serum levels of RLP were significantly higher in the patients than in the normal subjects. The oxidation of RLP may therefore be involved in the progression of atherosclerosis in patients with IHD or DM.
No takes yet. Share an insight, caveat, or question.
Tamura et al. (1997) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: