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August 16, 2026Journal of Reproductive and Infant PsychologyOpen Access

Long-term outcomes of first episode affective psychosis in postpartum women

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Authors

ATAthanasios TsoumprisGLGabriella LewisALAmelia Lapraik

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Overview

Cohort study reveals distinct morbidity trajectories and high postpartum recurrence risk in women with first-episode postpartum psychosis, highlighting elevated long-term mortality.

Key Points

  • Characterize the long-term clinical course, mortality, and outcomes of first-episode postpartum psychosis compared to first-episode non-postpartum psychosis.
  • Conducted a single-center retrospective cohort study (N=1011) comparing postpartum psychosis with non-postpartum psychosis, adjusting for prior psychiatric illness.
  • Applied k-means clustering to identify outcome trajectories and generated multivariable models to predict clinical prognosis.
  • Women with postpartum psychosis had fewer subsequent deliveries and an elevated readmission rate during subsequent postpartum periods (0.55 admissions/delivery).
  • Annual mortality in the postpartum psychosis group reached 871 per 100,000 person-years, approximately 11.3 times the local population norm.
  • K-means clustering defined two distinct long-term clinical trajectories following first-episode postpartum psychosis, separating patients into higher and lower future morbidity courses.

Cite This Study

Tsoumpris et al. (2026) studied this question.

synapsesocial.com/papers/6a81791ff2fb91fc834ac518https://doi.org/10.1080/02646838.2026.2714056
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early-Onset and Delayed-Onset Postpartum Psychosis: A Case Series2025
  2. 2Pregnancy in the shadow of psychosis: Navigating first‐time motherhood with increased likelihood of postpartum psychosis and postnatal depression2024
  3. 3Persistent Psychosis During 4 Years after First Hospitalization for a Psychotic Disorder in the Suffolk County Mental Health Project: Prevalence, Risk Factors, and Relationship to 25-Year Outcomes2026
  4. 4Clinical illness course and family-related outcomes among parents with a first episode of schizophrenia spectrum disorder: a 20-year follow-up of the OPUS trial2024 · 2 citations
  5. 5Long-Term Outcomes in First-Episode Psychosis: Insights from a 20-Year Cohort Study to Inform Recovery-Oriented Care Models2025