What does this research mean for the field?

There is a critical lack of data to guide the management of epilepsy during the menopause transition, particularly regarding how hormone therapy affects seizure control and antiseizure medication metabolism. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To synthesize current evidence on how hormonal changes and menopausal hormone therapy affect seizure frequency and antiseizure medication metabolism in women with epilepsy.

August 16, 2026Neurology Clinical Practice

The Menopause Transition and Epilepsy

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Authors

KSKelsey M. Smith SFStephanie S. Faubion LVLata Vadlamudi

Discussion

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Overview

Narrative review highlights limited clinical data on hormone therapy and seizure control in menopausal women with epilepsy, suggesting an urgent need for targeted management guidelines.

Key Points

To synthesize current evidence on how hormonal changes and menopausal hormone therapy affect seizure frequency and antiseizure medication metabolism in women with epilepsy.
Narrative review summarizing published literature on perimenopause, menopause, seizure control, hormone therapy, and nonhormonal symptom management in individuals with epilepsy.
Hormone therapy effectively relieves vasomotor, mood, and sleep disturbances but may alter seizure control and accelerate the clearance of antiseizure medications such as lamotrigine.
A substantial lack of clinical trial data regarding hormone therapy safety in women with epilepsy often deters clinicians from prescribing effective menopause treatments.

Cite This Study

Smith et al. (2026) studied this question.

synapsesocial.com/papers/6a81791ff2fb91fc834ac5ad https://doi.org/10.1212/cpj.0000000000200650

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August 16, 2026Neurology Clinical Practice

The Menopause Transition and Epilepsy

View Full Paper

Ask AI

Bookmark

Authors

KSKelsey M. Smith SFStephanie S. Faubion LVLata Vadlamudi

Discussion

Member takes

Overview

Narrative review highlights limited clinical data on hormone therapy and seizure control in menopausal women with epilepsy, suggesting an urgent need for targeted management guidelines.

Key Points

To synthesize current evidence on how hormonal changes and menopausal hormone therapy affect seizure frequency and antiseizure medication metabolism in women with epilepsy.
Narrative review summarizing published literature on perimenopause, menopause, seizure control, hormone therapy, and nonhormonal symptom management in individuals with epilepsy.
Hormone therapy effectively relieves vasomotor, mood, and sleep disturbances but may alter seizure control and accelerate the clearance of antiseizure medications such as lamotrigine.
A substantial lack of clinical trial data regarding hormone therapy safety in women with epilepsy often deters clinicians from prescribing effective menopause treatments.

Cite This Study

Smith et al. (2026) studied this question.

synapsesocial.com/papers/6a81791ff2fb91fc834ac5ad https://doi.org/10.1212/cpj.0000000000200650

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