It was found that compounds combining diazaadamantane and monoterpenoid fragments are potent inhibitors of new structural type of human recombinant DNA repair enzyme Tyrosyl-DNA phosphodiesterase I (Tdp1). It was demonstrated that the inhibition efficiency depended on the length and flexibility of the aliphatic chain of the substituent.
No takes yet. Share an insight, caveat, or question.
Захаренко et al. (2015) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: