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August 16, 2026Journal of Cerebrovascular and Endovascular NeurosurgeryOpen Access

Willisian collateral and carotid stenosis during large vessel occlusion stroke: Observations from computed tomography angiography

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Authors

RKRuba KiwanSLStephen Lownie

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Overview

Observational study reveals ophthalmic artery size correlates with stroke severity in large vessel occlusion, highlighting the role of native collateral pathways.

Key Points

  • To determine the relationship between the anatomical size of major cranial collateral arteries and stroke severity in patients with large vessel occlusion.
  • Analyzed 100 consecutive patients with large vessel occlusion stroke undergoing endovascular thrombectomy.
  • Measured 16 candidate arteries (diameter ≥1 mm) using axial source computed tomography angiography (CTA).
  • Evaluated correlations with admission NIHSS, ASPECTS, and multiphasic CTA collateral scores using multivariable analysis.
  • A 1-mm increase in ipsilateral ophthalmic artery diameter was associated with a 4.8-point decrease in NIHSS score (p < 0.008) and a 1.53-point increase in ASPECTS (p < 0.001).
  • An increase in contralateral ophthalmic artery diameter correlated with poorer outcomes, showing a 6.3-point increase in NIHSS score and a 2.6-point decrease in ASPECTS.

Cite This Study

Kiwan et al. (2026) studied this question.

synapsesocial.com/papers/6a81794cf2fb91fc834ac6a2https://doi.org/10.7461/jcen.2026.e2026.02.004
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