October 20, 2015Current Medical Research and Opinion

Adherence to non-vitamin-K-antagonist oral anticoagulant medications based on the Pharmacy Quality Alliance measure

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Why the study?

Does rivaroxaban improve medication adherence compared to dabigatran or apixaban in adult patients using NOACs?

Population

21,175 adult patients from the Humana database with ≥2 dispensings of NOAC agents in 2014, at least 180 days…

Comparison

Rivaroxaban vs Dabigatran and apixaban

Design

Cohort

Authors

CMColleen A. McHorneyWisconsin Department of Health Services CCConcetta CriveraJohnson & Johnson (United States)FLFrançois LalibertéGroup for Research in Decision Analysis

Discussion

Member takes

Implication

Adherence differences among NOACs in claims data should not yet change prescribing; leaves open causal effects on persistence.

Structured PICO

Does rivaroxaban improve medication adherence compared to dabigatran or apixaban in adult patients using NOACs?

Population

21,175 adult patients from the Humana database with ≥2 dispensings of NOAC agents (rivaroxaban, dabigatran, or apixaban) in 2014, at least 180 days apart, with >60 days of supply, and ≥180 days of continuous enrollment prior to the index NOAC.

Intervention

Rivaroxaban

Comparator

Dabigatran and apixaban

Outcome

Medication adherence based on the Pharmacy Quality Alliance (PQA) measure (proportion of days covered [PDC] ≥0.8)

Rivaroxaban users demonstrated significantly higher medication adherence compared to apixaban and dabigatran users based on the PQA measure in a retrospective claims database analysis.

Limitations

potential inaccuracies in claims data
possible change in patterns over time
impossibility of knowing whether all supplied tablets were taken

Cite This Study

McHorney et al. (2015) studied this question.

synapsesocial.com/papers/6a81796e267334e2baf09d48 https://doi.org/10.1185/03007995.2015.1096242

Topics

Anticoagulation in AF

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Adherence to non-vitamin-K-antagonist oral anticoagulant medications based on the Pharmacy Quality Alliance measure

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Adherence to non-vitamin-K-antagonist oral anticoagulant medications based on the Pharmacy Quality Alliance measure

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider