What question did this study set out to answer?

To review the molecular mechanisms connecting apoptosis and autophagy and evaluate emerging bioengineering and drug delivery strategies for selective cancer cell destruction.

August 16, 2026Open Access

Engineering Cell Death Pathways for Cancer Therapy: Emerging Concepts in Apoptosis and Autophagy

View Full Paper

Ask AI

Bookmark

Authors

PTPratik Umesh Parikh1*, Dr. Gunjan Jadon2, Dr. Vipul Patel3, Dr. P K Choudhary4, Dr. Awadh Kishor5, Rushikesh Mohite6, Sakshi Kapure6, Lahu Tandale6

Discussion

Member takes

Implication

Review demonstrates pathway engineering of apoptosis and autophagy in tumor cells, suggesting multi-target biomarker-guided combinations overcome drug resistance.

Key Points

To review the molecular mechanisms connecting apoptosis and autophagy and evaluate emerging bioengineering and drug delivery strategies for selective cancer cell destruction.
Synthesized molecular pathways controlling intrinsic and extrinsic apoptosis, autophagy, and key crosstalk regulators including mTOR, BCL-2/Beclin-1, and p53.
Assessed pathway manipulation tools, including BH3 mimetics, epigenetic modulators, CRISPR/Cas9, RNA interference, and nanoparticle-based delivery platforms alongside AI-driven discovery.
Identified existing cell death modulators (such as venetoclax, temsirolimus, hydroxychloroquine, and everolimus) that face clinical challenges including drug resistance, poor delivery, and tumor heterogeneity.
Concluded that biomarker-guided, locally delivered, multi-target combination therapies outperform single-pathway approaches in selectively activating programmed cell death.

Cite This Study

Pratik Umesh Parikh1*, Dr. Gunjan Jadon2, Dr. Vipul Patel3, Dr. P K Choudhary4, Dr. Awadh Kishor5, Rushikesh Mohite6, Sakshi Kapure6, Lahu Tandale6 (2026) studied this question.

synapsesocial.com/papers/6a817980f2fb91fc834acaa7 https://doi.org/10.5281/zenodo.21915720

View Full Paper

Ask AI

Bookmark

Implication

Review demonstrates pathway engineering of apoptosis and autophagy in tumor cells, suggesting multi-target biomarker-guided combinations overcome drug resistance.

Engineering Cell Death Pathways for Cancer Therapy: Emerging Concepts in Apoptosis and Autophagy

Discussion

Member takes

Implication

Key Points

Cite This Study

Engineering Cell Death Pathways for Cancer Therapy: Emerging Concepts in Apoptosis and Autophagy

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider