What question did this study set out to answer?

To evaluate redox imbalance, lipid peroxidation, antioxidant enzyme defenses, and nitric oxide bioavailability in patients with post-COVID-19 syndrome across different durations of illness.

August 16, 2026AntioxidantsOpen Access

Persistent Redox Imbalance in Post-COVID-19 Syndrome: Lipid Peroxidation, Antioxidant Enzyme Depletion, and Reduced Nitric Oxide Availability in an Amazonian Population

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Authors

RSRenata Cunha SilvaUniversidade do Estado do Pará JQJuarez Antônio Simões QuaresmaUniversidade do Estado do Pará BMBruno Kenji Hosoda MineshitaUniversidade do Estado do Pará

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Implication

Observational study reveals persistent redox imbalance and depleted antioxidant enzymes in post-COVID-19 syndrome, indicating sustained oxidative and vascular stress regardless of disease duration.

Key Points

To evaluate redox imbalance, lipid peroxidation, antioxidant enzyme defenses, and nitric oxide bioavailability in patients with post-COVID-19 syndrome across different durations of illness.
Conducted a cross-sectional observational study comparing 85 patients with post-COVID-19 syndrome to 53 healthy controls.
Assessed TBARS, total antioxidant capacity (ABTS), plasma nitric oxide levels, and erythrocyte SOD, CAT, and GPx activities, analyzing subgroups stratified by symptom duration (≤6, 6–12, and >12 months).
Patients with post-COVID-19 syndrome exhibited significantly higher TBARS concentrations and significantly lower nitric oxide, ABTS, SOD, CAT, and GPx levels compared to healthy controls, with predominantly large effect sizes.
Lipid peroxidation showed a positive correlation with HDL-c levels in affected individuals.
Biomarker levels of redox and antioxidant status did not differ significantly across symptom duration subgroups (≤6, 6–12, and >12 months).

Cite This Study

Silva et al. (2026) studied this question.

synapsesocial.com/papers/6a817980f2fb91fc834acb54 https://doi.org/10.3390/antiox15081013

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Implication

Observational study reveals persistent redox imbalance and depleted antioxidant enzymes in post-COVID-19 syndrome, indicating sustained oxidative and vascular stress regardless of disease duration.

Persistent Redox Imbalance in Post-COVID-19 Syndrome: Lipid Peroxidation, Antioxidant Enzyme Depletion, and Reduced Nitric Oxide Availability in an Amazonian Population

Discussion

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Implication

Key Points

Cite This Study

Persistent Redox Imbalance in Post-COVID-19 Syndrome: Lipid Peroxidation, Antioxidant Enzyme Depletion, and Reduced Nitric Oxide Availability in an Amazonian Population

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Implication

Key Points

Cite This Study

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