What does this research mean for the field?

Iatrogenic cerebral amyloid angiopathy is most frequently reported in Japan, is primarily linked to cranial surgery involving cadaveric dura mater, and can present in patients over 55 without acute intracerebral hemorrhage. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To systematically characterize the published global distribution, age-related clinical spectrum, and exposure characteristics of iatrogenic cerebral amyloid angiopathy.

August 16, 2026Journal of Neurology Neurosurgery & PsychiatryOpen Access

Iatrogenic cerebral amyloid angiopathy: a scoping review

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Authors

SIShuhei Ikeda THTsuyoshi Hamaguchi THTeruyuki Hirano

Discussion

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Overview

Scoping review uncovers a 36-year latency and varied clinical presentations across 94 iatrogenic cerebral amyloid angiopathy cases, highlighting the need for lifelong surgical exposure tracking.

Key Points

To systematically characterize the published global distribution, age-related clinical spectrum, and exposure characteristics of iatrogenic cerebral amyloid angiopathy.
Conducted a PRISMA-compliant scoping review searching MEDLINE, Scopus, and Ichushi-Web from inception to January 31, 2026.
Retrospectively screened and classified reported cases using broad exposure criteria and the revised Queen Square framework.
Included 57 reports describing 94 cases, with Japan contributing the largest share of published cases.
Identified cranial surgery with cadaveric dura mater (n=44) as the primary exposure, with a median exposure age of 4 years, median latency of 36 years, and median presentation age of 42 years.
Observed acute intracerebral haemorrhage at initial presentation in 58 cases, which occurred less frequently in patients with disease onset at or after 55 years of age.

Cite This Study

Ikeda et al. (2026) studied this question.

synapsesocial.com/papers/6a8179cbf2fb91fc834ad1ce https://doi.org/10.1136/jnnp-2026-339381

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August 16, 2026Journal of Neurology Neurosurgery & PsychiatryOpen Access

Iatrogenic cerebral amyloid angiopathy: a scoping review

View Full Paper

Ask AI

Bookmark

Authors

SIShuhei Ikeda THTsuyoshi Hamaguchi THTeruyuki Hirano

Discussion

Member takes

Overview

Scoping review uncovers a 36-year latency and varied clinical presentations across 94 iatrogenic cerebral amyloid angiopathy cases, highlighting the need for lifelong surgical exposure tracking.

Key Points

To systematically characterize the published global distribution, age-related clinical spectrum, and exposure characteristics of iatrogenic cerebral amyloid angiopathy.
Conducted a PRISMA-compliant scoping review searching MEDLINE, Scopus, and Ichushi-Web from inception to January 31, 2026.
Retrospectively screened and classified reported cases using broad exposure criteria and the revised Queen Square framework.
Included 57 reports describing 94 cases, with Japan contributing the largest share of published cases.
Identified cranial surgery with cadaveric dura mater (n=44) as the primary exposure, with a median exposure age of 4 years, median latency of 36 years, and median presentation age of 42 years.
Observed acute intracerebral haemorrhage at initial presentation in 58 cases, which occurred less frequently in patients with disease onset at or after 55 years of age.

Cite This Study

Ikeda et al. (2026) studied this question.

synapsesocial.com/papers/6a8179cbf2fb91fc834ad1ce https://doi.org/10.1136/jnnp-2026-339381

View Full Paper

Ask AI

Bookmark