What question did this study set out to answer?

To assess whether combining serial cranial ultrasound features—including haemorrhage grade, parenchymal lesions, and ventricular morbidity—improves neurodevelopmental risk stratification in very preterm infants.

August 16, 2026Journal of Clinical MedicineOpen Access

Beyond Maximum Haemorrhage Grade: Serial Cranial Ultrasound Phenotyping Refines Developmental Risk Stratification After Intraventricular Haemorrhage in Very Preterm Infants

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Authors

NNNoemí Núñez‐EnamoradoUniversidad Complutense de Madrid ACAna Camacho-SalasUniversidad Complutense de Madrid MLMaría López-MaestroHospital Universitario 12 De Octubre

Discussion

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Implication

Cohort study demonstrates that serial cranial ultrasound phenotyping refines neurodevelopmental risk prediction in very preterm infants, suggesting improved bedside counselling and follow-up.

Key Points

To assess whether combining serial cranial ultrasound features—including haemorrhage grade, parenchymal lesions, and ventricular morbidity—improves neurodevelopmental risk stratification in very preterm infants.
Analyzed a single-centre cohort of N=2756 very preterm infants (from 3081 eligible) who underwent at least two protocolised serial cranial ultrasound (CUS) examinations.
Tracked maximum IVH grade, visible associated parenchymal lesions (visible APL), severe ventriculomegaly (VM), post-haemorrhagic hydrocephalus (PHH), cerebral palsy (CP), school-age cognitive sequelae, and sustained educational support.
Among infants with grade 3 IVH, visible APL occurred in 60.5%, severe VM in 40.8%, and PHH in 21.7%.
Cerebral palsy occurred in 1.4% of the reference group (no IVH/visible APL), 2.9% with isolated grade 1 IVH, 2.8% with isolated grade 2 IVH, and 27.5% with isolated grade 3 IVH (adjusted OR 28.55, 95% CI 11.31–72.11).
Adjustment for severe VM attenuated the CP risk for isolated grade 3 IVH to an aOR of 12.94, while severe VM remained independently associated with CP, cognitive sequelae, and sustained developmental support.

Cite This Study

Núñez‐Enamorado et al. (2026) studied this question.

synapsesocial.com/papers/6a8179cbf2fb91fc834ad257 https://doi.org/10.3390/jcm15166310

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August 16, 2026Journal of Clinical MedicineOpen Access

Beyond Maximum Haemorrhage Grade: Serial Cranial Ultrasound Phenotyping Refines Developmental Risk Stratification After Intraventricular Haemorrhage in Very Preterm Infants

View Full Paper

Ask AI

Bookmark

Authors

NNNoemí Núñez‐EnamoradoUniversidad Complutense de Madrid ACAna Camacho-SalasUniversidad Complutense de Madrid MLMaría López-MaestroHospital Universitario 12 De Octubre

Discussion

Member takes

Implication

Cohort study demonstrates that serial cranial ultrasound phenotyping refines neurodevelopmental risk prediction in very preterm infants, suggesting improved bedside counselling and follow-up.

Key Points

To assess whether combining serial cranial ultrasound features—including haemorrhage grade, parenchymal lesions, and ventricular morbidity—improves neurodevelopmental risk stratification in very preterm infants.
Analyzed a single-centre cohort of N=2756 very preterm infants (from 3081 eligible) who underwent at least two protocolised serial cranial ultrasound (CUS) examinations.
Tracked maximum IVH grade, visible associated parenchymal lesions (visible APL), severe ventriculomegaly (VM), post-haemorrhagic hydrocephalus (PHH), cerebral palsy (CP), school-age cognitive sequelae, and sustained educational support.
Among infants with grade 3 IVH, visible APL occurred in 60.5%, severe VM in 40.8%, and PHH in 21.7%.
Cerebral palsy occurred in 1.4% of the reference group (no IVH/visible APL), 2.9% with isolated grade 1 IVH, 2.8% with isolated grade 2 IVH, and 27.5% with isolated grade 3 IVH (adjusted OR 28.55, 95% CI 11.31–72.11).
Adjustment for severe VM attenuated the CP risk for isolated grade 3 IVH to an aOR of 12.94, while severe VM remained independently associated with CP, cognitive sequelae, and sustained developmental support.

Cite This Study

Núñez‐Enamorado et al. (2026) studied this question.

synapsesocial.com/papers/6a8179cbf2fb91fc834ad257 https://doi.org/10.3390/jcm15166310

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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