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August 16, 2026Green Chemistry Letters and ReviewsOpen Access

Integration of deep eutectic solvents into green bioprocesses for bioactive extraction

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Authors

KAKhalid M. AbedHTHind H. ThwainiBKBadoor M. Kurji

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Overview

Review demonstrates the efficacy of deep eutectic solvents for extracting bioactive compounds, highlighting scalable and sustainable green bioprocess applications.

Key Points

  • To review the 2022–2025 developments in deep eutectic solvents (DES) and natural deep eutectic solvents (NADES) for sustainable bioactive compound extraction.
  • Reviewed foundational and recent literature (2022–2025) on DES and NADES formulations for extracting bioactives from plant and marine sources.
  • Assessed integration with extraction technologies, including ultrasonication and microwave-assisted processes.
  • Evaluated physicochemical mechanisms, formulation-dependent toxicity, biodegradability, and industrial scaling constraints.
  • DES and NADES formulations modulate melting points and enhance the solubility of phenolics, flavonoids, and essential oils through hydrogen-bond donor and acceptor interactions.
  • Coupling DES/NADES with intensification methods such as ultrasonication and microwaves enhances extraction efficiency, though standardized protocols and optimized energy consumption remain critical challenges for industrial adoption.

Cite This Study

Abed et al. (2026) studied this question.

synapsesocial.com/papers/6a8179cbf2fb91fc834ad2f2https://doi.org/10.1080/17518253.2026.2710927
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