Observational study reveals a linear inverse association between perinatal 25(OH)D and postpartum depression in new mothers, indicating strong predictive screening utility.
Key Points
To investigate the dose-response relationship between perinatal serum 25(OH)D concentrations and postpartum depression risk, while evaluating its utility as a predictive biomarker.
Enrolled 326 perinatal women and measured serum 25(OH)D levels at 24–48 hours postpartum.
Assessed postpartum depression status within 6 weeks after delivery using Edinburgh Postnatal Depression Scale (EPDS) scores to evaluate dose-response trends, risk factors, and ROC predictive performance.
Observed a linear negative dose-response relationship between perinatal serum 25(OH)D concentrations and postpartum depression risk.
Serum 25(OH)D demonstrated high screening accuracy for postpartum depression (AUC = 0.822), with an optimal cutoff value of 24.26 ng/mL yielding 67.11% sensitivity and 85.20% specificity.
Identified primiparity and fair spousal relationship as risk factors, whereas planned pregnancy, sunlight exposure, and oral vitamin D supplementation provided protective effects.