What does this research mean for the field?

A comprehensive, multimodal personalised prehabilitation intervention for individuals with acute myeloid leukaemia and high-risk myelodysplastic syndrome can be successfully developed using a theory- and evidence-based approach that incorporates extensive patient and carer input. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To develop a theory- and evidence-based, multimodal personalized prehabilitation intervention for individuals undergoing consolidation treatment for acute myeloid leukaemia and high-risk myelodysplastic syndrome.

August 16, 2026NIHR Open ResearchOpen Access

Development of a multi-modal PeRsOnalised PrEhabilitation intervention for people with acute myeloid Leukaemia: the PROPEL trial

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To develop a theory- and evidence-based, multimodal personalized prehabilitation intervention for individuals undergoing consolidation treatment for acute myeloid leukaemia and high-risk myelodysplastic syndrome.
Followed the Medical Research Council framework for complex interventions, integrating behavioural science and Acceptance and Commitment Therapy principles.
Conducted needs assessments using scoping reviews, stakeholder prioritization, and surveys of healthcare professionals, patients, and carers.
Designed remote delivery protocols and training materials for evaluation in a UK multicentre phase III randomized trial (ISRCTN17655532).
Generated a multiphasic Personalised Prehabilitation Care Plan incorporating tailored exercise regimens, targeted nutritional support, and emotional wellbeing modules.
Embedded behavioural change strategies designed for remote delivery during remission consolidation chemotherapy and haematopoietic stem cell transplantation.

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Implication

Randomized trial protocol describes a multimodal personalized prehabilitation intervention for acute myeloid leukaemia, indicating its potential to enhance treatment tolerance and recovery.

Cite This Study

Hall et al. (2026) studied this question.

synapsesocial.com/papers/6a8179eff2fb91fc834ad609 https://doi.org/10.3310/nihropenres.14245.1

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Implication

Randomized trial protocol describes a multimodal personalized prehabilitation intervention for acute myeloid leukaemia, indicating its potential to enhance treatment tolerance and recovery.

Development of a multi-modal PeRsOnalised PrEhabilitation intervention for people with acute myeloid Leukaemia: the PROPEL trial

Key Points

Discussion

Implication

Cite This Study

Development of a multi-modal PeRsOnalised PrEhabilitation intervention for people with acute myeloid Leukaemia: the PROPEL trial

Key Points

Discussion

Implication

Cite This Study

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