Provide practical, systematic crystallization and solubility-based workflows to enable medicinal chemists to isolate target compounds directly from crude reaction mixtures.
Designed antisolvent-based direct-drop crystallization workflows categorized by aqueous miscible and aqueous immiscible reaction solvents.
Established reslurry and recrystallization strategies utilizing LCMS retention factors to guide solvent selection for selective impurity purging.
Demonstrated workflow execution across two medicinal chemistry project case studies.
Direct-drop crystallization protocols eliminated the need for routine chromatography by successfully precipitating target molecules from crude reaction mixtures.
Implementation of standardized antisolvent workflows in two medicinal chemistry case studies significantly accelerated project delivery timelines.
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