What question did this study set out to answer?

To provide an updated global overview of adverse drug reactions associated with propofol using spontaneous reporting data from the WHO VigiAccess platform.

August 16, 2026MedicineOpen Access

Global pharmacovigilance overview of adverse drug reactions associated with propofol

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Authors

NANasser M. AlorfiUmm al-Qura University AAAmmar AlDabbaghSoliman Fakeeh Hospital MAMansour M. AlourfiSoliman Fakeeh Hospital

Discussion

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Implication

Retrospective study observes frequent skin and vascular reactions in patients given propofol, highlighting the importance of continuous safety monitoring.

Key Points

To provide an updated global overview of adverse drug reactions associated with propofol using spontaneous reporting data from the WHO VigiAccess platform.
Retrospective descriptive analysis of N=45,354 spontaneous adverse drug reaction (ADR) reports from the WHO-VigiAccess database retrieved on October 26, 2025.
Categorized ADRs according to the Medical Dictionary for Regulatory Activities (MedDRA) System Organ Class and stratified data by geographical region, sex, and age group without individual causality assessments.
The most common ADR categories were skin and subcutaneous tissue disorders (12%), vascular disorders (12%), general disorders and administration site conditions (11%), nervous system disorders (9%), respiratory disorders (9%), immune disorders (8%), and cardiac disorders (8%).
Reports were most frequently submitted from Europe and the Americas, occurred in slightly higher proportions in male patients, predominantly affected adults aged 45 to 64 years, and showed a continuous increase over the past two decades.

Cite This Study

Alorfi et al. (2026) studied this question.

synapsesocial.com/papers/6a817a33f2fb91fc834ade75 https://doi.org/10.1097/md.0000000000050189

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Implication

Retrospective study observes frequent skin and vascular reactions in patients given propofol, highlighting the importance of continuous safety monitoring.

Global pharmacovigilance overview of adverse drug reactions associated with propofol

Discussion

Member takes

Implication

Key Points

Cite This Study

Global pharmacovigilance overview of adverse drug reactions associated with propofol

Discussion

Member takes

Implication

Key Points

Cite This Study

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