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Experimental study demonstrates palladium-catalyzed sequential isocyanide insertion in Passerini adducts, indicating a versatile route to complex heterocycles.
The study reports a Pd-catalyzed chemoselective sequential isocyanide insertion at sp3- and sp2-carbon centers, which enables the controlled incorporation of two or four isocyanide units. This cascade process, derived from readily accessible Passerini adducts, provides a divergent platform for the rapid assembly of diverse N- and O-containing heterocycles. The strategy overcomes the limitations of single-site reactions and offers high selectivity and structural complexity in heterocycle synthesis.
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Ren et al. (2026) studied this question.
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