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August 16, 2026World Journal of Microbiology and BiotechnologyOpen Access

Environmental filtering shapes biosynthetic potential and resistome of antarctic microbiomes

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Authors

WMWilliam Bartolomeu MedeirosKHKelly J. Hidalgo-MartinezDPDaniel D. P. S. Penna

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Overview

Genome-resolved metagenomic analysis reveals geochemical gradients shape biosynthetic diversity and antimicrobial resistomes in Antarctic microbiomes, highlighting their biotechnological potential.

Key Points

  • To investigate how geochemical gradients and environmental filtering shape biosynthetic gene clusters (BGCs) and antimicrobial resistance genes (ARGs) across Antarctic microbial communities.
  • Analyzed 319 medium- to high-quality metagenome-assembled genomes (MAGs) recovered from four Antarctic sites: Whalers Bay, Crater Lake, Fumarole Bay, and Hannah Point.
  • Integrated genome-resolved metagenomics, biosynthetic mining, resistome profiling, network analyses, and geochemical correlation assessments.
  • Identified 1,197 BGCs, with terpene clusters accounting for over 25% of the total and notable biosynthetic hotspots like an Acidobacteriota MAG carrying 62 BGCs.
  • Resistome profiles showed significant site-specific variation linked to geochemical factors, particularly cobalt, iron, organic carbon, and thermal fluctuations.
  • Identified co-localization of biosynthetic and resistance determinants in Pseudomonadota and Actinomycetota MAGs, indicating functional coupling between secondary metabolism and self-resistance mechanisms.

Cite This Study

Medeiros et al. (2026) studied this question.

synapsesocial.com/papers/6a817a4cf2fb91fc834ae11ahttps://doi.org/10.1007/s11274-026-05201-8
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