DWI-Positive Lesions in Patients With Acute Intracerebral Hemorrhage

Martina Locatelli; Hatice Özkan; Giulia Avola; Philip S. Nash; Gareth Ambler; Simon Fandler‐Höfler; Yang Du; Wenpeng Zhang; Robert Simister; David J. Werring; Hans Rolf Jäger

doi:10.1212/wnl.0000000000218449

August 14, 2026NeurologyOpen Access

DWI-Positive Lesions in Patients With Acute Intracerebral Hemorrhage

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Key Points

To determine the prevalence, anatomical distribution, and associations of DWI-positive lesions with baseline clinical-radiologic features and 6-month functional outcomes in acute intracerebral hemorrhage.
Analyzed consecutive patients with acute intracerebral hemorrhage enrolled in the Stroke Investigation Group in North and Central London registry.
Evaluated acute MRI scans for DWI-positive lesions and cerebral small vessel disease markers according to STandards for ReportIng Vascular changes on nEuroimaging criteria.
Performed adjusted multivariable logistic regression to determine associations with baseline features and poor 6-month functional outcome defined as modified Rankin Scale score ≥3.
DWI-positive lesions were independently associated with severe white matter hyperintensities (OR 3.37, 95% CI 2.72–6.89) and cerebral microbleeds (OR 1.61, 95% CI 1.21–2.93).
DWI-positive lesions were independently associated with intracerebral hemorrhage volume ≥30 mL (OR 2.29, 95% CI 1.76–3.42).
Presence of DWI-positive lesions independently predicted poor 6-month functional outcome (OR 2.16, 95% CI 1.67–3.48).

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Implication

Prospective cohort study shows DWI-positive lesions independently predict poor 6-month functional outcomes in acute intracerebral hemorrhage, highlighting their value as prognostic biomarkers.

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Cite This Study

Locatelli et al. (2026) studied this question.

synapsesocial.com/papers/6a817a60f2fb91fc834ae2ed https://doi.org/10.1212/wnl.0000000000218449

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DWI-Positive Lesions in Patients With Acute Intracerebral Hemorrhage

Key Points

No abstract yet

Implication

Discussion

Cite This Study

DWI-Positive Lesions in Patients With Acute Intracerebral Hemorrhage

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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