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August 16, 2026Ophthalmic and Physiological OpticsOpen Access

Impact of Optical Coherence Tomography Scan Pattern and Chorio-Scleral Interface Delineation on Choroidal Vascularity Index Measurements

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Authors

KWKryshell Yu Qi WongRCRachel Ka Man ChunDADavid Alonso‐Caneiro

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Overview

Observational study finds radial and raster OCT scans yield similar choroidal vascularity index values in healthy adults, highlighting boundary standardization needs.

Key Points

  • To compare radial and horizontal raster spectral-domain OCT scan patterns and evaluate the impact of different chorio-scleral interface boundary delineations on choroidal vascularity index measurements.
  • Analyzed 25 eyes from 25 healthy adults (aged 21–31 years, 72% female, mean spherical equivalent −2.97 ± 2.02 D) using 12-line radial and 31-line horizontal raster scans with enhanced depth imaging.
  • Manually measured CVI across three posterior chorio-scleral interface boundaries (upper vascular, middle vascular–stromal, and lower stromal) and evaluated agreement via Bland-Altman analysis and two-way repeated-measures ANOVA across 6-mm ETDRS subfields.
  • Mean CVI differences ranged from 1.43% to 2.38% between upper and middle boundaries, 1.23% to 2.04% between middle and lower boundaries, and 2.90% to 4.42% between upper and lower boundaries.
  • Scan patterns demonstrated good agreement with a coefficient of variation <2%; raster scans measured 0.51% higher CVI in the central fovea, while radial scans measured 0.64–1.10% higher CVI perifoveally.
  • Significant differences between scan patterns appeared only in the outer temporal subfield (−1.10%, p = 0.005) and outer ring (−0.77%, p = 0.02), with lowest overall CVI values found in the outer nasal subfield, nasal quadrant, and outer ring.

Cite This Study

Wong et al. (2026) studied this question.

synapsesocial.com/papers/6a817a72f2fb91fc834ae4a7https://doi.org/10.1007/s44402-026-00159-4
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