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August 16, 2026CureusOpen Access

Ovarian Carcinoma Presenting Mucoepidermoid Carcinoma-Like Features in Association With Seromucinous Borderline Tumor: A Real Seromucinous Carcinoma?

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Authors

KIKentaro IshidaANAyaka NakamuraATAtsuko Taga

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Overview

Case report reveals aggressive mucoepidermoid-like carcinoma arising from an ovarian seromucinous borderline tumor, suggesting an endometriosis-independent pathway.

Key Points

  • To characterize a rare ovarian carcinoma with mucoepidermoid carcinoma-like features arising directly from a seromucinous borderline tumor.
  • Performed histopathologic and immunohistochemical evaluation (including PAX8, cytokeratin 20, and p40) on a 10-cm pelvic tumor from a 56-year-old postmenopausal female.
  • Conducted comprehensive genomic profiling to evaluate somatic mutations across key cancer-related genes, including KRAS, CTNNB1, PTEN, and ARID1A.
  • Histopathology demonstrated a transition from a seromucinous borderline tumor to invasive carcinoma with p40-positive cells and diffuse PAX8 positivity across primary and nodal metastatic sites.
  • Genomic profiling revealed a KRAS p.G12D mutation without alterations in CTNNB1, PTEN, or ARID1A.
  • The tumor exhibited platinum resistance and rapid progression, resulting in patient death 11 months after initial diagnosis.

Cite This Study

Ishida et al. (2026) studied this question.

synapsesocial.com/papers/6a817a91f2fb91fc834ae717https://doi.org/10.7759/cureus.114557
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Seromucinous borderline tumor-associated high-grade ovarian cancers2024
  2. 2Seromucinous borderline ovarian tumors: Clinical and ultrasound characteristics and association with endometriosis2026
  3. 3A Case of Ovarian Seromucinous Borderline Tumor With a Predominant Serous Component Suggesting Serous Borderline Tumor With Mucinous Differentiation2026 · 1 citations
  4. 4CK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritonei2024 · 1 citations
  5. 5Borderline seromucinous tumor with pre-existing endometriosis - A case report2024